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A number of randomised clinical trials and observational scientific studies have revealed an association concerning utilization of non-steroidal anti-inflammatory prescription drugs (NSAIDs) and increased chance of coronary heart failure, but the danger and dose-reaction relation connected to particular person NSAIDs is basically not known

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Editor's Notice: For good reasons of community wellness, audience ought to be knowledgeable that this letter has become “heavily and uncritically cited” as evidence that addiction is uncommon with opioid therapy. Leung et al. describe its background.

Associations have been assessed by multivariable conditional logistic regression versions. The dose-reaction relation amongst NSAID use and coronary heart failure threat was also assessed.

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Each and every databases longitudinally recorded information on Every member of its goal populace, such as demographic data, clinic discharge diagnoses, and outpatient drug prescriptions.

Our study experienced some restrictions. Firstly, our study won't have captured all NSAID publicity, since A few of these medicines (eg, ibuprofen) will also be obtainable about the counter in many of the four nations around the world. Consequently, individuals categorized as non-existing customers of NSAIDs In this particular study may actually have been present-day people of around the counter NSAIDs.

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